Best Anti Aging Serum: Our Top 15 Picks

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When consumers think of anti-aging serums, they typically believe that it is a product for the older individual with plenty of “life” lines on their face. The fact of the matter is that consumers, women, in particular, are looking for the best anti-aging serums at younger and younger ages.


Because they want to get ahead of the aging process.

Is that even possible? The answer is, well, maybe.

Let’s face it, there is no stopping the aging process, but there are products on the market that can help bring back the youthful glow we once had before life and all its pollutants got to us and clogged up and otherwise damaged our skin.

Woman putting a serum on her hand

Photo form: Unsplash

Buyer’s Guide to Choosing an Anti-Aging Serum: What Shoppers Should Look For

So do anti-aging serums actually work? While some products claim to be able to turn the clock back, there simply isn’t enough evidence to prove that these serums work. However, there are some ingredients in these serums that have been shown to be both safe and effective.

With so many products on the market, how do we know which ones are the best anti-aging serums to use that will give us the desired results? Looking through lists of ingredients can be very intimidating, so we have compiled a short buyer’s guide to which ingredients shoppers should be on the look for when looking for an anti-aging serum.

A Hydrator

A good hydrator such as Aloe Vera should be a key ingredient in any anti-aging serum. This will help add water to the skin. The skin, like any other organ of the body, needs to remain hydrated in order to function properly. The added hydration also plays a vital part in your skin looking healthier and younger.  


Antioxidants help to combat environmental stressors which can increase the appearance of aging. So it is essential to have an anti-aging serum that contains antioxidants and vitamins such as vitamin C to help lighten and brighten the skin.


Retinol, a vitamin A derivative, helps to treat fine lines, wrinkles, sun spots, dull skin and so much more. Jeffrey Dover, an associate clinical professor of dermatology at the Yale School of Medicine states that it is one of the “best anti-aging ingredients we have.”


Yes, sunscreen.

Sunscreen helps keep the skin from prematurely wrinkling, sagging and getting blotchy in color by protecting it from harmful UV rays. These rays destroy collagen and elastin fibers, and anti-aging serums with sunscreen included help to fight off these rays to prevent damage from starting.

Alpha Hydroxy Acids

According to Sherry Ingraham, M.D, a dermatologist in Texas, Alpha Hydroxy Acids such as Glycolic acid, lactic acid, and others help t gently exfoliate the skin to give it a “smoother, brighter appearance and stimulate new collagen.”


Lipids are often listed as ceramides and fatty acids, and both are beneficial to bringing our skin’s plumpness back.

“Ceramides are essentially the skin barrier molecules deficient in dry skin. Fatty acids help drive the production of cholesterol and ceramides and might be listed as sunflower or other oils,” according to Ingraham.

How We Chose Our Ratings

Our focus is to provide you, the consumers with an honest look at products on the market.

That being said, after looking over hundreds of reviews, we tallied up our own totals to give each product in our top 15 best anti-aging serums list with a rating out of 5 stars.

Our totals are based on overall consumer ratings, product reliability and overall quality of the product. In the case of a ratings tie, we took the overall price into consideration in order to keep the consumer’s best interest in mind.

Top 15 Best Anti-Aging Serums

When it comes to the best anti-aging serums on the market, there are quite literally thousands of different options. Based on our rating system mentioned above, here is our top 15 list of best anti-aging serums:

1. Avon Anew Clinical Line Eraser with Retinol Treatment

Avon Anew Clinical Line Eraser with Retinol Treatment 1 Ounce
  • Contains retinol (#1 anti-wrinkle ingredient recommended by dermatologists)
  • Contains Amino Acid complex for wrinkle-fighting action.
  • Lightweight, quickly absorbs, good for all skin types
  • Fragrance-free and oil-free, Allergy-tested and dermatologist-tested, Non-comedogenic and non-acnegenic
  • 1 oz. net wt.

Avon’s Anew Clinical line eraser with retinol treatment delivers a formula that can visibly reduce both fine lines and wrinkles. When used regularly, consumers noticed a major change in the appearance of lines and wrinkles.

Price: $

This naturally-derived lactic acid from sugar cane is combined with pink clay and zinc gluconate to help absorb excess sebum, to control shine and help minimize the appearance of pores for a smoother, more refined texture.

This formula is Enriched with anti-oxidant boosting iris extract and composed of 88% natural-origin ingredients.

Price: $$

3. Neutrogena Hydro Boost Gel-Cream Extra-Dry Skin

Neutrogena Hydro Boost Hyaluronic Acid Hydrating Face Moisturizer Gel-Cream to Hydrate and Smooth Extra-Dry Skin, 1.7 oz
  • 1.7-ounce jar of Neutrogena Hydro Boost Daily gel-cream face moisturizer with hyaluronic acid quenches extra-dry skin
  • The moisturizing gel formula provides rapid hydration to skin, leaving it looking smooth and supple by restoring skin's natural barrier against moisture loss
  • Hyaluronic acid, a hydrator found naturally in the skin, attracts moisture and locks it in
  • Daily hydrating face moisturizer features a non-comedogenic formula that is oil-free, dye-free, and fragrance-free and is from a dermatologist-recommended brand
  • The rich face lotion relieves intense dryness by providing long-lasting moisturizing power This hyaluronic acid moisturizer is the perfect addition to your at-home hydrating self-care routine

This hydro boost gel-cream helps to instantly quench and provide long-lasting moisture relief for your extra-dry skin. This unique gel-cream formula absorbs quickly like a gel into the skin and has the long-lasting moisturizing power of a cream.

This gel-cream features hyaluronic acid, which is naturally found in the skin. Hyaluronic acid acts as a sponge for dry skin cells moisturizing with up to 1,000 times its weight in water. This formula is said to result in more supple, healthy and smooth looking skin.

Price: $

4. Dr. Hauschka Regenerating Serum

Dr. Hauschka Regenerating Serum, 1 Fl Oz
  • This activating serum firms and revitalizes mature skin
  • Features revitalizing kalanchoe and organic clover blossom honey
  • Encourages skin natural cellular renewal

This activating serum helps to firm and revitalize mature skin. It features revitalizing kalanchoe and organic clover blossom honey which encourages the skin’s natural cellular renewal. This formula reduces the appearance of wrinkles and fine lines.  

Price: $$

5. L’Oreal Age Perfect Hydra-Nutrition Advanced Skin Repair Serum

L'Oréal Paris Age Perfect Hydra Nutrition Advanced Skin Repair Serum, 1 fl. oz.
  • L’Oreal Paris Age Perfect Hydra-Nutrition Daily Serum for mature skin reverses signs of past damage and aging with Nutri-Repair Complex and strengthens skin
  • This face serum instantly replenishes skin’s protective moisture barrier and skin appears more naturally radiant
  • After 4 weeks of using L’Oreal Paris Age Perfect Hydra-Nutrition face serum, elasticity is improved for more toned, resilient skin
  • For best results apply each day and night on freshly cleansed skin before applying moisturizer or as a light weight replacement to moisturizer - Place 2-3 droplets into hand and smooth on face and neck
  • This face serum was Dermatologist tested for gentleness and is non-comedogenic, does not tend to cause blocked pores

Restore your skin’s youthful glow with the help of L’Oreal’s Age Perfect Glow Renewal Facial Oil. It helps to deeply nourish and replenish dull, dry skin with a unique blend of 8 Essential oils. The non-greasy and lightweight formula absorb into the skin quickly for all-day hydration.

Price:  $


This intense beauty serum has been tested in an independent 12-month trial where the fining show that it has genuine, long-term anti-aging benefits. This formula features retinyl palmitate, antioxidants, firming peptides and alfalfa extract to reduce the appearance of deep lines and wrinkles by up to 50% in just four weeks.

Price:   $

7. Estée Lauder Advanced Night Repair

ESTEE LAUDER Advanced Night Repair Recovery Complex Ii, 1.7 Ounce
  • It maximizes the power of skin's natural nighttime renewal with our exclusive ChronoluxCB Technology
  • Fragrance free
  • Ideal for multiple signs of aging, visible age prevention, dryness, dehydration, lines, wrinkles, dullness, and loss of radiance

This night repair serum addresses all key signs of visible aging thanks to the exclusive ChronoluxCB technology for more comprehensive and precise nighttime repair. This serum promotes a natural nighttime purification process that is vital to helping users achieve younger-looking skin.

Price:   $$

8. SkinCeuticals Resveratrol B E

SKINCEUTICALS Resveratrol B E, 1 Fl Oz
  • Neutralizes age-accelerating internal free radicals
  • Promotes skin's natural repair to diminish the visible signs of accumulated damage
  • Strengthens functionality to resist new damage
  • Ideal for normal, dry, and combination skin types

This antioxidant cream helps neutralize age-accelerating internal free radicals while promoting the skin’s natural ability to repair itself in order to diminish the visible sign of accumulated damage. This cream is ideal for normal, dry and combination skin types.

Price:   $$

9. Elizabeth Arden Prevage Anti-Aging Daily Serum

Elizabeth Arden Prevage Anti-Aging Daily Serum, 2.0 with Idebenone, 1.7 Oz
  • It's formulated with advanced idebenone technology
  • This serum protects and corrects the look of skin
  • Helping shield it from environmental assaults

This firming serum helps to protect and correct the look of skin, all while helping shield it from environmental assaults and intercepting future aging signs.

This serum is fortified with Idebenone, the most powerful antioxidant available today. Idebenone dramatically improves the look of skin while noticeably minimizing the appearance of lines, wrinkles, age spots, and discolorations and giving skin a firm look, tests show a reduction in the appearance of redness and minor scars.

Price:   $$$

10. RoC Retinol Correxion Anti-Aging Deep Wrinkle Serum

RoC Retinol Correxion Deep Wrinkle Retinol Face Serum with Ascorbic Acid, Daily Anti-Aging Skin Care Treatment, Stocking Stuffer, 1 Ounce (Packaging May Vary)
  • HOLIDAY GIFT: Give the gift of self care and beauty this holiday to the person who has everything. RoC's award winning skincare make thoughtful gifts for women and men, for whatever holiday you celebrate! Ideal as a Christmas stocking stuffer, White Elephant, Secret Santa, or Hanukkah gift for anyone on your list — mom, dad, grandma, friend, husband, or wife!
  • ANTI-WRINKLE SERUM TREATMENT: Visibly reduce the signs of aging skin. This potent formula with antioxidants powered by Roc Retinol is clinically proven to deliver smoother, firmer, more radiant-looking skin & help reduce appearance of deep wrinkles. Gentle enough for daily use by men and women.
  • PROVEN RESULTS: With daily use, this serum is clinically proven to help deliver smoother, more radiant skin in 4 weeks & diminish the look of photodamage in 8 weeks. Deep wrinkles appear visibly reduced. Non-greasy. Non-comedogenic. Dermatologist-tested.
  • ANTI-AGING FORMULAS: Whether you're looking for a solution for deep wrinkles, fine lines, dark circles, crow's feet, uneven skin tone or dry skin, we have an anti-aging formula that's right for you.
  • SCIENCE & BEAUTY: We produce a wide array of skin care products & treatments including daily moisturizers with SPF, hyaluronic and niacinamide acids, facial cleansers, vitamin C serums, retinol skin tone & wrinkle regimens & creams for under eyes, neck firming, decollete & much more.

This RoC anti-aging serum helps to visibly reduce the appearance of both fine lines and deep wrinkles. After four weeks, users reported that their skin was more radiant and fine lines were smoothed, and skin firmness was improved.

Price:   $

11. Olay Pro-X Anti-Aging Hydra Firming Cream

Wrinkle Cream by Olay Professional Pro-X Deep Wrinkle Treatment Anti Aging 1.0 Fl Oz (Packaging may vary)
  • Designed and professionally tested for the deepest wrinkles
  • Specialized Treatment penetrates deep into your skin's surface, hydrating to combat the appearance of wrinkles
  • Treat skin morning and night by applying Deep Wrinkle Treatment to areas of concern, including crow's feet area
  • Light, Non-Greasy Formula; Dermatologically Tested; Non-Comedogenic (won't clog pores)

Pro-X Hydra Firming Cream is professionally designed as a primary solution that helps optimize elasticity and firmness by plumping and locking in moisture. This cream was designed and tested to resignal skin to perform more like it did when it was younger, giving users younger looking skin. This formula glides on easily and absorbs quickly, leaving your skin feeling smooth and velvety and is reportedly ideal for use under makeup.

Price:   $

12. Drunk Elephant T.L.C. Framboos Glycolic Night Serum

Drunk Elephant T.L.C. Framboos Glycolic Night Serum - Skin Care Brightening Night Serum, 1 Ounce…
  • T.L.C. FRAMBOOS GLYCOLIC NIGHT SERUM. A 12% AHA/BHA night serum that helps refine and resurface skin to reveal a smoother and more radiant looking complexion. It enhances the performance of other products by clearing the way for maximum absorption
  • WHAT IT IS FORMULATED TO DO. This high-tech gel resurfaces dull skin and gently lifts dead skin cells away for a clear, smooth, and even looking complexion. It delivers precise chemical exfoliation without harsh side effects like dryness or sensitization
  • NO QUESTION IN QUALITY. A routine is only as good as its worst product, and a product is only as good as its worst ingredient. Drunk Elephant is dedicated to your internal health and external skin health; "If there's any DOUBT, it's OUT.
  • SENSITIVE VS. SENSITIZED. When skin is exposed to irritants and sensitizers, damage can be imperceptible and cumulative, leaving it in a reactive mode. "Sensitive" skin is often just skin that has become sensitized over time by harsh additives
  • MADE IN THE USA. Drunk Elephant doesnt take shortcuts or compromise ingredients to save money. They are hands-on and will stay true to their ethos. Their products are designed, tested and made in the United States. Drunk Elephant is certified cruelty-free, they have never, nor will ever, animal test or allow products to be tested on animals.

This high-tech gel resurfaces dull, congested skin while gently lifting dead skin cells away by gently dissolving the glue that holds them to the surface. This results in greater clarity and a smoother, more even-toned complexion. This Serum I s formulated with a dream team AHA/BHA blend that includes glycolic, lactic, tartaric, citric and salicylic acids and blended with raspberry extract.

Price:   $$

13. Olay Regenerist Luminous Skin Tone Perfecting Serum

Olay Regenerist Tone, 1.3 fl oz
  • Note: This product does not have an expiration date, but a printed manufacturing date listed on the packaging.
  • Visibly fades the appearance of dark spots to reveal more even-toned, younger-looking skin
  • Exfoliates, smoothes, and brightens to reveal a more even, balanced skin tone. Ingredients: Water, Niacinamide, Pentylene Glycol, Butylene Glycol, Polymethylsilsesquioxane, Ethylhexyl Palmitate, Dimethicone, Undecylenoyl Phenylalanine, Silica, Boron Nitride, Ascorbyl Glucoside, Polyglyceryl-2 Oleate, Glucosyl Hesperidin, Dimethiconol, Aminomethyl Propanol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Polyglyceryl-10 Oleate, Polysorbate 20, Sodium Benzoate, Disodium Edta, Benzyl Alcohol, Phenoxyethanol, Fragrance. *Vitamin B3
  • Lightweight, non-greasy formula hydrates quickly to reveal more beautiful skin in just 1 week
  • Diminishes the look of dark spots and discoloration in 4 weeks and Regenerates skin’s youthful look 10 surface layers deep

The Olay Regenerist Luminous Tone Perfecting Treatment helps to reveal your most beautiful, pearlescent skin. Users reported seeing visibly fading dark spots and discoloration in just four weeks as this tone perfecting treatment regenerated their youthful glow.

Price:   $

14. Paula’s Choice Resist Intensive Wrinkle-Repair Retinol Serum

Paula's Choice RESIST Intensive Wrinkle-Repair Retinol Serum, Squalane, Vitamin C & E, Anti-Aging & Wrinkle Treatment, 1 Ounce
  • PURE RETINOL DELIVERS VISIBLE RESULTS--With stable retinol and soothing antioxidants this unique serum addresses the appearance of wrinkles improves the feel of firmness uneven skin tone and red marks and leaves your face looking perfectly radiant.
  • Paula's Choice--RESIST Intensive Wrinkle-Repair Serum contains brightening Vitamin C alongside stabilized retinol to improve the appearance of wrinkles. This silky-smooth serum is infused with antioxidants & skin-replenishing & -hydrating ingredients.
  • Use Paula's Choice RESIST Intensive Wrinkle-Repair Retinol Serum twice daily as part of your morning & evening skin care routines along with your favorite Paula's Choice cleanser, toner, serums, spot treatments & moisturizer with SPF for daytime wear.
  • Paula's Choice products are made with YOUR SKIN in mind. Whatever your skincare concern, whether dryness, acne, fine lines, or sensitive skin; we've got a treatment line for you. The search for amazing skin care ends here. Finally, you found it.
  • Paula's Choice Skincare makes products that work. No fragrance, no parabens, no fluff. Just effective, science-backed formulas that target any concern from wrinkles to breakouts.

The RESIST Intensive Wrinkle-Repair Retinol Serum is an exclusive formulate that contains a unique blend of highly stabilized retinol, vitamin-derived antioxidants, and soothing anti-aging plant extracts. This unique combination helps to address and treat the appearance of wrinkles, to visibly improve the feel of firmness, uneven skin tone, and red marks and leaves skin looking radiant.

Price:   $$

15. Shiseido Bio-Performance Lift Dynamic Serum

Shiseido Bio-Performance Liftdynamic Serum, 1 oz
  • Skin Friendly Ingredients
  • Help To Boost Your Appearance
  • Keep It Smooth And Radiant

This multi-benefit sculpting serum supports skin’s natural restorative powers to give it a lifted and firmed appearance for a more youthful look.

Price:   $$

Not All Anti-Aging Serums Are Created Equally

woman with her hand on cheek

Image source: Unsplash

Not only have we looked at some of the best anti-aging serums currently on the market, but we’ve also shared our buyer’s guide to which ingredients you should look for in your serum.

So, what’s next?

While we highly suggest checking out some of the anti-aging serums we mentioned above, we understand that not all anti-serums are created equally. That also means that no one serum is going to work for everyone and every skin type.

This means that consumers really need to dive in and do some extra research on their own. That being said, you’ll need to ask yourself a few questions.

First of all, what do you want this serum to do for your skin?

Then, of course, you’ll want to ask yourself how much you are willing to spend as prices can range from drugstore to high-end when it comes to the best anti-aging serums.

Finally, you’ll want to spend time looking into the ingredients included in your top picks. Some products are harsher than others and can cause more side-effects than benefits. Knowing ahead of time what is in your products and how they react to your skin can save you a lot of time, money and, in many cases, pain from severe reactions.

Final Thoughts: Do Your Research

Moral of the story?

Research, research, research!

Use our buyer’s guide and our top 15 list for guidance and then start narrowing down your choices from there.

It may seem a little overwhelming, but if you take your time, you are sure to find an anti-aging serum that checks off all your boxes.

Last update on 2021-12-09 / Affiliate links / Images from Amazon Product Advertising API

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